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Scientific stuff

Mitarbeiter
Dr.-Ing. Jochen Schmid

Scientific stuff

Tel.: +49 (0) 9421 187-331
Fax: +49 (0) 9421 187-310
E-Mail: j.schmid@tum.de

TUM Campus Straubing
Schulgasse 16
94315 Straubing

Schulgasse 16 Room: 1.A06

Vita

 

Curriculum:

  • Forschungsaufenthalt bei CONICET/PROIMI, Tucumán, Argentinien (2015)
  • Kurzaufenthalte an der Universidade Nova de Lisboa und University of Copenhagen (2013)
  • Zukunftsforum Biotechnologie der DECHEMA (Sprecher seit 2013)
  • Seit 2012 Habilitation im Bereich der Mikrobiellen Polymere
  • Forschungsaufenthalt an der Keio Universität in Japan (2012)
  • Seit 2010 Gruppenleiter der Abteilung Metabolic Engineering & Mikrobielle Polysaccharide am Lehrstuhl für Chemie Biogener Rohstoffe.
  • Seit 2009 Postdoc am Lehrstuhl für Chemie Biogener Rohstoffe
  • Wissenschaftlicher Mitarbeiter am Institut für Mikrobiologie und Genetik der TU-Berlin (2008-2009)
  • Promotion am Institut für Mikrobiologie und Genetik der TU-Berlin (2005-2008) zum Thema „Genetics of Scleroglucan Production by Sclerotium rolfsii“ bei Prof. Stahl und Vera Meyer
  • Diplomarbeit an der Charité Berlin, Campus Virchow Klinikum Experimentelle Chirurgie (2005)
  • Studium der Biotechnologie an der Technischen Universität Berlin (1998-2005)
  • Ausbildung zum Brauer und Mälzer bei der Gold Ochsen GmbH in Ulm (1996-1998)

Research:

  • Synthetische Biosynthesecluster für mikrobielle Polysaccharide
  • Synthetische Chemo-Enzymatische Kaskaden-Reaktionen
  • Aufklärung der Biosynthese mikrobieller Polysaccharide
  • Untersuchung fungaler Enzymsysteme
  • Genom Editierung
  • Metabolic Engineering

Publications:

  1. Schmid, J., Recent insights in microbial exopolysaccharide biosynthesis and engineering strategies. Current Opinion in Biotechnology, 2018. 53: p. 130-136.
    doi:10.1016/j.copbio.2018.01.005
  2. Rütering, M., J. Schmid, M. Gansbiller, A. Braun, J. Kleinen, M. Schilling, and V. Sieber, Rheological characterization of the exopolysaccharide Paenan in surfactant systems. Carbohydrate Polymers, 2018. 181: p. 719-726.
    doi:10.1016/j.carbpol.2017.11.086
  3. Rütering, M., B. F. Cress, M. Schilling, B. Rühmann, M. A. G. Koffas, V. Sieber, and J. Schmid, Tailor-made exopolysaccharides—CRISPR-Cas9 mediated genome editing in Paenibacillus polymyxa. Synthetic Biology, 2017. 2(1): p. ysx007-ysx007.
    doi:10.1093/synbio/ysx007
  4. Funk I, Sieber V, Schmid J (2017) “Effects of glucose concentration on 1,18-cis-octadec-9-enedioic acid biotransformation efficiency and lipid body formation in Candida tropicalis.” Scientific Reports 7(1): 13842.
    doi:10.1038/s41598-017-14173-7
  5. Funk I, Rimmel N, Schorsch C, Sieber V, Schmid J (2017) Production of dodecanedioic acid via biotransformation of low cost plant-oil derivatives using Candida tropicalis, Journal of Industrial Microbiology & Biotechnology, 1-12 doi: 10.1007/s10295-017-1972-6
  6. Koenig S, Rühmann B, Sieber V, Schmid J (2017) Quantitative Assay of β-(1,3)–β-(1,6)–Glucans from Fermentation Broth Using Aniline Blue. Carbohydr Polym.
    doi.org/10.1016/j.carbpol.2017.06.047
  7. Schmid J, Harnisch F (2017) Das neue Wissenschaftszeitvertragsgesetz: Intention und Status quo!?
    BioSpektrum 23(2):119-119
    doi: 10.1007/s12268-017-0773-9
  8. Harnisch, F. and J. Schmid (2017) From emergence to consolidation or peaks: Riding the waves of bioengineering.
    Engineering in Life Sciences:17(1): p. 4-5.
  9. Loscar ME, Huptas C, Wenning M, Sieber V, Schmid J (2016) Draft Genome Sequence of Lysinibacillus xylanilyticus SR-86. Genome Announcements, 4(6):e01317-01316.
    doi:10.1128/genomeA.01317-16
  10. Pick A, Beer B, Hemmi R, Momma R, Schmid J, Miyamoto K, Sieber V (2016) Identification and characterization of two new 5-keto-4-deoxy-D-Glucarate Dehydratases/Decarboxylases. BMC Biotechnology. 16(1): p. 80.
  11. Schmid J, Huptas C, Wenning M (2016) Draft Genome Sequence of the Xanthan Producer Xanthomonas campestris LMG 8031. Genome Announcements 4(5).
  12. Rütering M, Schmid J, Rühmann B, Schilling M, Sieber V (2016) Controlled production of polysaccharides – exploiting nutrient supply for levan and heteropolysaccharide formation in Paenibacillus sp.. Carbohydrate Polymers 148, 326-334.
  13. Rühmann B, Schmid J, Sieber V (2016) Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis. J Vis Exp, 110(e53249).
    doi:10.3791/53249
  14. Spiekermann A, Schmid J (2016) Damit sie wissen, was sie tun – Constructive Alignment soll zielgerichtetes Lernen fördern. Deutsche Universitäts Zeitung, 04/16.
  15. Schmid J, Farina J, Rehm B, Sieber V (2016) Editorial: “Microbial Exopolysaccharides: From genes to applications”. Frontiers in Microbiology, 7.
    doi 10.3389/fmicb.2016.00308
  16. Schmid J, Heider D, Wendel N.J, Sperl N, Sieber V (2016) Bacterial Glycosyltransferases: Challenges and opportunities of a highly diverse enzyme class toward tailoring natural products. Frontiers in Microbiology, 7.
    doi.org/10.3389/fmicb.2016.00182
  17. Blombach B, Castiglione K, Haarmann T, and Schmid J (2015) Trends in der Genomeditierung für die industrielle Biotechnologie. BIOspektrum 21(7): 788-790.
  18. Schmid J, Muffler K (2015) Grüne Gentechnologie – der Ratio eine Chance. BIOspektrum 2(4): 367-367.
  19. Rühmann B, Schmid J, and Sieber V (2015) Methods to identify the unexplored diversity of microbial exopolysaccharides. Frontiers in Microbiology 6.
    doi 10.3389/fmicb.2015.00565
  20. Schmid J, Sieber V and Rehm B (2015) Bacterial exopolysaccharides: Biosynthesis pathways and engineering strategies. Frontiers in Microbiology 6.
    doi 10.3389/fmicb.2015.00496
  21. Pick A, Schmid J and Sieber V (2015) Characterization of uronate dehydrogenases catalysing the initial step in an oxidative pathway. Microbial Biotechnology. doi: 10.1111/1751-7915.12265
  22. Schmid J and Sieber V (2015) Enzymatic Transformations Involved in the Biosynthesis of Microbial Exo-polysaccharides Based on the Assembly of Repeat Units. ChemBioChem.
    doi: 10.1002/cbic.201500035
  23. Reese J d, Sperl N, Schmid J, Sieber V and Plank J (2015) Effect of biotechnologically modified alginates on LDH structures. Bioinspired, Biomimetic and Nanobiomaterials 1-34.
    10.1680/bbn.14.00032
  24. Rühmann B, Schmid J and Sieber V (2015) High throughput exopolysaccharide screening platform: From strain cultivation to monosaccharide composition and carbohydrate fingerprinting in one day. Carbohydrate Polymers 122(0): 212-220.
    doi:10.1016/j.carbpol.2014.12.021
  25. Schmid J, Sieber V (2014) Weiße Gentechnologie – Von Vitaminen & Aromen zu Industriechemikalien Band 8 der Schriftenreihe Gentechnik für Umwelt und Verbraucherschutz – 5. Fachtagung Gentechnik. pdf
  26. Schmid J, Sperl N, Sieber V (2014) A comparison of genes involved in sphingan biosynthesis brought up to date. Appl Microbiol Biotechnol:1-15.
    doi:10.1007/s00253-014-5940-z
  27. Pick A, Ott W, Howe T, Schmid J, Sieber V (2014) Improving the NADH-cofactor specificity of the highly active AdhZ3 and AdhZ2 from Escherichia coli K-12. Journal of Biotechnology (0).
    doi:10.1016/j.jbiotec.2014.06.015 
  28. Schmid J, Koenig S, Pick A, Steffler F, Yoshida S, Miyamoto K, Sieber V (2014) Draft Genome Sequence of Kozakia baliensis SR-745, the First Sequenced Kozakia Strain from the Family Acetobacteraceae. Genome Announcements 2 (3).
    doi:10.1128/genomeA.00594-14.
  29. Bühler FH B, Junker B, Junne S, Kuepfer L, Mao L, Marienhagen J, Muffler K, Noack S, Olbrich C, Rihko-Struckmann L, Schallmey A, Schmid J, Stafforst T, Steingroewer J, Zurbriggen M (ed) (2014) Biotechnologie – der Schlüssel zur Bioökonomie. Dechema Diskussionspaper Vol 1.
    doi:http://biotech.dechema.de/Publikationen.html
  30. Ruhmann B, Schmid J, Sieber V (2014) Fast carbohydrate analysis via liquid chromatography coupled with ultra violet and electrospray ionization ion trap detection in 96-well format. Journal of chromatography A 1350:44-50.
    doi:10.1016/j.chroma.2014.05.014
  31. Schmid J, Koenig S, Rühmann B, Rütering M, Sieber V (2014) Biosynthese und Genomik mikrobieller Polysaccharide. Biospektrum 20 (3):288-290. doi:10.1007/s12268-014-0443-0
  32. Pick A, Rühmann B, Schmid J, Sieber V (2012) Novel CAD-like enzymes from Escherichia coli  K-12 as additional tools in chemical production. Appl. Microbiol. Biotechnol
    doi:10.1007/s00253-012-4474-5.
  33. Schmid J, Meyer V, Sieber V (2011) Scleroglucan: Biosynthesis, production and application of a versatile hydrocolloid. Appl. Microbiol. Biotechnol.: 91(4):937-947.
  34. Schmid J, Müller-Hagen D, Bekel T, Funk L, Stahl U, Sieber V, Meyer V (2010) Transcriptome sequencing and comparative transcriptome analysis of the scleroglucan producer Sclerotium rolfsii. BMC Genomics 11:329.
  35. Schwartlander R, Schmid J, Brandenburg B,Katenz E, Wolfgang F, Vondran F, Pless G, Cheng X.D, Pascher A, Neuhaus P, Sauer I.M (2007) Continuously microscopically observed and process-controlled cell culture within the SlideReactor: Proof of a new concept for cell characterization. Tissue Engineering, 13, 187-196.
  36. Schwartlander R, Schmid J, Katenz E, Cheng X, Pless G, Modest D, Vondran F, Neuhaus P, Sauer I.M (2006) The slidereactor – Proof of concept. International Journal of Artificial Organs, 29, 519-519.
  37. Sauer I.M, Schwartlander R, Schmid J, Efimova E, Vondran F.W.R, Kehr D, Pless G, Spinelli A, Brandenburg B, Hildt E, Neuhaus P (2005) The SlideReactor – A simple hollow fiber based bioreactor suitable for light microscopy. Artificial Organs, 29, 264-267.

Buchartikel 

  1. Schmid, J., B. Rühmann, V. Sieber, L. Romero-Jiménez, J. Sanjuán, and D. Pérez-Mendoza, Screening of c-di-GMP-Regulated Exopolysaccharides in Host Interacting Bacteria, in Host-Pathogen Interactions: Methods and Protocols, C. Medina and F.J. López-Baena, Editors. (2018), Springer New York: New York, NY. p. 263-275.
  2. Clavel T, Mendez D.F, Schmid J, Kolossa S, Matzke L (2015) Das interdisziplinäre Forschungsseminar; Erkenntnisse aus dem Pilotprojekt INDISNET. In: Neues Handbuch Hochschullehre, Ausgabe 72, Signatur E1.11, (Hrsg.) Behrend, Fleischmann, Schaper, Szczyrba, Wildt
  3. Schmid J, Mueller-Hagen D, Sieber V, Meyer V (2013). Nucleic and Protein Extraction Methods for Fungal Exopolysaccharide Producers. In: Laboratory Protocols in Fungal Biology. V. K. Gupta, M. G. Tuohy, M. Ayyachamy, K. M. Turner and A. O’Donovan, Springer New York: 427-434.
  4. Schmid J, Stahl U, Meyer V (2009) Genetic and Metabolic Engineering in Filamentous Fungi. In: Physiology and Genetics. The Mycota Vol 15: 377-392.

 

 

 

Contact

Chair of Chemistry of Biogenic Resources

Schulgasse 16
D-94315 Straubing

Head

Prof. Dr. Volker Sieber

Phone: +49 (0) 9421 187-300
Phone: +49 (0) 8161 71 35 91
Mail: sieber@tum.de

Team Assistant

Elisabeth Aichner

Phone: +49 (0) 9421 187-301
Mail: elisabeth.aichner@tum.de