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  • Stockmann, PN, Pastoetter DL, Woelbing M, Falcke C, Winnacker M, Strittmatter H, Sieber V (2019) New Bio‐Polyamides from Terpenes: α‐Pinene and (+)‐3‐Carene as Valuable Resources for Lactam Production. Macromolecular rapid communications, 1800903.
    doi: 10.1002/marc.201800903
  • Gansbiller M, Schmid J, Sieber V (2019) In-depth rheological characterization of genetically modified xanthan-variants
    doi: 10.1016/j.carbpol.2019.02.055
  • Zachos I, Nowak C, Sieber V (2019) Biomimetic cofactors and methods for their recycling, Current Opinion in Chemical Biology, 49, pp 59-66
    doi: 10.1016/j.cbpa.2018.10.003


  • Ranganathan S, Sieber V (2018) Recent Advances in the Direct Synthesis of Hydrogen Peroxide Using Chemical Catalysis— A Review, Catalysts 8(9), 379
    doi: 10.3390/catal8090379
  • Schwarz D, Schoenenwald AKJ, Dörrstein J, Sterba J, Kahoun D, Fojtíková P, Vilímek J, Schieder D, Zollfrank C, Sieber V (2018) Biosynthesis of poly-3-hydroxybutyrate from grass silage by a two-stage fermentation process based on an integrated biorefinery concept, Bioresource Technology, Volume 269, pp 237-245, ISSN 0960-8524
    doi: 10.1016/j.biortech.2018.08.064
  • Sutiono S, Carsten J, Sieber V (2018) Structure‐Guided Engineering of α‐Keto Acid Decarboxylase for the Production of Higher Alcohols at Elevated Temperature ChemSusChem11, 3335.
    doi: 10.1002/cssc.201800944
  • Beer B, Pick A, Döring M, Lommes P, Sieber V (2018) Substrate scope of a dehydrogenase from Sphingomonas species A1 and its potential application in the synthesis of rare sugars and sugar derivatives Microbial Biotechnology 0(0), 1–12
  • Sperl JM and Sieber V (2018) Multienzyme Cascade Reactions—Status and Recent Advances. ACS Catal.8, pp 2385–2396
  • Ortiz-Tena JG, Rühmann B and Sieber V (2018) Colorimetric Determination of Sulfate via an Enzyme Cascade for High-Throughput Detection of Sulfatase Activity. Anal. Chem., 90 (4), pp 2526–2533
  • Rütering M, Schmid J, Gansbiller M, Braun A, Kleinen J, Schilling M, and Sieber V (2018)Rheological characterization of the exopolysaccharide Paenan in surfactant systems. Carbohydrate Polymers, 2018. 181: p. 719-726.


  • Hohagen H, Schwarz D, Schenk G, Guddat LW, Schieder D, Carsten J, Sieber V (2017) Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade Bioresource Technology 245(A), 1084-1092.
  • Rütering M, Cress BF, Schilling M, Rühmann B, Koffas M A G, Sieber V, and Schmid J, Tailor-made exopolysaccharides—CRISPR-Cas9 mediated genome editing in Paenibacillus polymyxa. Synthetic Biology, 2017. 2(1): p. ysx007-ysx007.
  • doi:10.1093/synbio/ysx007
  • Funk I, Sieber V, Schmid J (2017) “Effects of glucose concentration on 1,18-cis-octadec-9-enedioic acid biotransformation efficiency and lipid body formation in Candida tropicalis.” Scientific Reports 7(1): 13842.
  • Iwanow M, Finkelmeyer J, Soeldner A, Kaiser M, Gaertner T, Sieber V, Koenig B (2017) Preparation of Supported Palladium Catalysts using Deep Eutectic Solvents Chemistry – A European Journal, 23(51), 12467-12470.
  • Nowak C, Pick A, Csepei L I, Sieber V (2017) Characterization of Biomimetic Cofactors According to Stability, Redox Potentials, and Enzymatic Conversion by NADH Oxidase from Lactobacillus pentosus. ChemBioChem
  • Inprakhon P, Wongthongdee N, Amornsakchai T, Pongtharankul T, Sunintaboon P, Wiemann L O, Durand A, Sieber V (2017) Lipase-catalyzed synthesis of sucrose monoester: Increased productivity by combining enzyme pretreatment and non-aqueous biphasic medium Journal of Biotechnology, 259, 182-190.
  • Roth S, Funk I, Hofer M, Sieber V (2017) Chemo-enzymatic synthesis of a novel borneol-based polyester. ChemSusChem 10(18)
    doi: 10.1002/cssc.201701146
  • Funk I, Rimmel N, Schorsch C, Sieber V, Schmid J (2017) Production of dodecanedioic acid via biotransformation of low cost plant-oil derivatives using Candida tropicalis, Journal of Industrial Microbiology & Biotechnology, 1-12
    doi: 10.1007/s10295-017-1972-6
  • Ranganathan S, Zeitlhofer S, Sieber V, (2017) Development of a lipase-mediated epoxidation process for monoterpenes in choline chloride-based deep eutectic solvents Green Chemistry, 19(11), 2576-2586.
  • Roth T, Beer B, Pick A, Sieber V, (2017) Thermostabilization of the uronate dehydrogenase from Agrobacterium tumefaciens by semi-rational design AMB Express (2017), 7(1), 1-9.
  • Obst U, Lu TK, Sieber V, (2017) A Modular Toolkit for Generating Pichia pastoris Secretion Libraries ACS Synthetic Biology, 6(6), 1016-1025.
  • Beer B, Pick A, Sieber V, (2017) In vitro metabolic engineering for the production of a-ketoglutarate Metabolic Engineering, 40, 5-13.
  • Nowak C, Pick A, Lommes P., and Sieber V (2017) Enzymatic Reduction of Nicotinamide Biomimetic Cofactors Using an Engineered Glucose Dehydrogenase – Providing a Regeneration System for Artificial Cofactors ACS Catal.
    doi: 10.1021/acscatal.7b00721
  • Koenig S, Rühmann B, Sieber V, Schmid J (2017) Quantitative Assay of β-(1,3)–β-(1,6)–Glucans from Fermentation Broth Using Aniline Blue. Carbohydr Polym.
  • Helfricht N, Doblhofer E, Bieber V, Lommes P, Sieber V, Scheibel T, Papastavrou G (2017) Probing the adhesion properties of alginate hydrogels: a new approach towards the preparation of soft colloidal probes for direct force measurements. Soft Matter.


  • Loscar ME, Huptas C, Wenning M, Sieber V, Schmid J (2016) Draft Genome Sequence of Lysinibacillus xylanilyticus SR-86. Genome Announcements, 4(6):e01317-01316.
  • Pick A, Beer B, Hemmi R, Momma R, Schmid J, Miyamoto K, Sieber V (2016) Identification and characterization of two new 5-keto-4-deoxy-D-Glucarate Dehydratases/Decarboxylases. BMC Biotechnology. 16(1): p. 80.
    doi: 10.1186/s12896-016-0308-3
  • Sperl JM, Carsten JM, Guterl J-K, Lommes P, Sieber V (2016) Reaction Design for the Compartmented Combination of Heterogeneous and Enzyme Catalysis. ACS Catalysis, 6(10):6329–6334.
  • Ranganathan S, Tebbe J, Wiemann LO, Sieber V (2016) Optimization of the lipase mediated epoxidation of monoterpenes using the design of experiments—Taguchi method. Process Biochemistry.
  • Schwarz D, Dörrstein J, Kugler S, Schieder D, Zollfrank C, Sieber V (2016) Integrated biorefinery concept for grass silage using a combination of adapted pulping methods for advanced saccharification and extraction of lignin. Bioresource Technology, 216:462-470.
  • Ortiz-Tena JG, Rühmann B, Schieder D, Sieber V (2016) Revealing the diversity of algal monosaccharides: Fast carbohydrate fingerprinting of microalgae using crude biomass and showcasing sugar distribution in Chlorella vulgaris by biomass fractionation. Algal Research, 17:227-235.
  • Rütering M, Schmid J, Rühmann B, Schilling M, Sieber V (2016) Controlled production of polysaccharides – exploiting nutrient supply for levan and heteropolysaccharide formation in Paenibacillus sp.. Carbohydrate Polymers 148, 326-334.
  • Rühmann B, Schmid J, Sieber V (2016) Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis. J Vis Exp, 110(e53249).
  • Schrepfer P, Buettner A, Goerner C, Hertel M, van Rijn J, Wallrapp F, Eisenreich W, Sieber V, Kourist R, Brück T (2016) Identification of amino acid networks governing catalysis in the closed complex of class I terpene synthases. Proceedings of the National Academy of Sciences, 113(8), E958-E967.
  • Schmid J, Farina J, Rehm B, Sieber V (2016) Editorial: “Microbial Exopolysaccharides: From genes to applications”. Frontiers in Microbiology, 7.
    doi 10.3389/fmicb.2016.00308
  • Schmid, J., Heider, D., Wendel, N.J., Sperl, N., Sieber, V. (2016). Bacterial Glycosyltransferases: Challenges and opportunities of a highly diverse enzyme class toward tailoring natural products. Frontiers in Microbiology, 7.
    doi: 10.3389/fmicb.2016.00182


  • Carsten, J. M., Schmidt, A. & Sieber, V. (2015). Characterization of recombinantly expressed dihydroxy-acid dehydratase from Sulfobus solfataricus-A key enzyme for the conversion of carbohydrates into chemicals. J Biotechnol 211, 31-41.
    doi: 10.1016/j.jbiotec.2015.06.384
  • Nowak, C., Beer, B., Pick, A., Roth, T., Lommes, P. & Sieber, V. (2015). A water-forming NADH oxidase from Lactobacillus pentosus suitable for the regeneration of synthetic biomimetic cofactors. Frontiers in Microbiology 6.
    doi: 10.3389/fmicb.2015.00957
  • Rühmann, B., Schmid, J. & Sieber, V. (2015). Methods to identify the unexplored diversity of microbial exopolysaccharides. Frontiers in Microbiology 6.
    doi: 10.3389/fmicb.2015.00565
  • Schmid, J., Sieber, V. & Rehm, B. (2015). Bacterial exopolysaccharides: Biosynthesis pathways and engineering strategies. Frontiers in Microbiology 6.
    doi: 10.3389/fmicb.2015.00496
  • Pick, A., Schmid, J. & Sieber, V. (2015). Characterization of uronate dehydrogenases catalysing the initial step in an oxidative pathway. Microbial Biotechnology 8, 633-643.
    doi: 10.1111/1751-7915.12265
  • de Reese, J., Sperl, N., Schmid, J., Sieber, V. & Plank, J. (2015). Effect of biotechnologically modified alginates on LDH structures. Bioinspired, Biomimetic and Nanobiomaterials 3, 1-13.
    doi: 10.1680/bbn.14.00032
  • Schmid, J. & Sieber, V. (2015). Enzymatic Transformations Involved in the Biosynthesis of Microbial Exo-polysaccharides Based on the Assembly of Repeat Units. ChemBioChem 16, 1141-1147.
    doi: 10.1002/cbic.201500035
  • Ranganathan, S., Gärtner, T., Wiemann, L. O. & Sieber, V. (2015). A one pot reaction cascade of in situ hydrogen peroxide production and lipase mediated in situ production of peracids for the epoxidation of monoterpenes. Journal of Molecular Catalysis B: Enzymatic 114, 72-76.
    doi: 10.1016/j.molcatb.2014.12.008
  • Rühmann, B., Schmid, J. & Sieber, V. (2015). High throughput exopolysaccharide screening platform: From strain cultivation to monosaccharide composition and carbohydrate fingerprinting in one day. Carbohydrate Polymers 122, 212-220.
    doi: 10.1016/j.carbpol.2014.12.021
  • Zachos, I., Gaßmeyer, S. K., Bauer, D., Sieber, V., Hollmann, F. & Kourist, R. (2015). Photobiocatalytic decarboxylation for olefin synthesis. Chemical Communications 51, 1918-1921.
    doi: 10.1039/C4CC07276F


  • Schmid, J., Sperl, N. & Sieber, V. (2014). A comparison of genes involved in sphingan biosynthesis brought up to date. Applied Microbiology and Biotechnology 98, 7719-7733.
    doi: 10.1007/s00253-014-5940-z
  • Tosstorff, A., Dennig, A., Ruff, A. J., Schwaneberg, U., Sieber, V., Mangold, K.-M., Schrader, J. & Holtmann, D. (2014). Mediated electron transfer with monooxygenases—Insight in interactions between reduced mediators and the co-substrate oxygen. Journal of Molecular Catalysis B: Enzymatic 108, 51-58.
    doi: 10.1016/j.molcatb.2014.06.011
  • Pick, A., Ott, W., Howe, T., Schmid, J. & Sieber, V. (2014). Improving the NADH-cofactor specificity of the highly active AdhZ3 and AdhZ2 from Escherichia coli K-12. Journal of Biotechnology 189, 157-165.
    doi: 10.1016/j.jbiotec.2014.06.015
  • Schmid, J., Koenig, S., Pick, A., Steffler, F., Yoshida, S., Miyamoto, K. & Sieber, V. (2014). Draft Genome Sequence of Kozakia baliensis SR-745, the First Sequenced Kozakia Strain from the Family Acetobacteraceae. Genome Announcements 2, e00594-14
    doi: 10.1128/genomeA.00594-14
  • Reiter, J., Pick, A., Wiemann, L., Schieder, D. & Sieber, V. (2014). Novel Natural NADH and NADPH Dependent Glutathione Reductase as Tool in Biotechnological Applications. JSM Biotechnol Bioeng 2, 1028.
    doi: link zum Artikel
  • Rühmann, B., Schmid, J. & Sieber, V. (2014). Fast carbohydrate analysis via liquid chromatography coupled with ultra violet and electrospray ionization ion trap detection in 96-well format. Journal of Chromatography A 1350, 44-50.
    doi: 10.1016/j.chroma.2014.05.014
  • Schmid, J., Koenig, S., Rühmann, B., Rütering, M. & Sieber, V. (2014). Biosynthese und Genomik mikrobieller Polysaccharide. BIOspektrum 20, 288-290.
    doi: 10.1007/s12268-014-0443-0
  • Pöhnlein, M., Slomka, C., Kukharenko, O., Gärtner, T., Wiemann, L. O., Sieber, V., Syldatk, C. & Hausmann, R. (2014). Enzymatic synthesis of amino sugar fatty acid esters. European Journal of Lipid Science and Technology 116, 423-428.
    doi: 10.1002/ejlt.201300380
  • Kourist, R., Guterl, J.-K., Miyamoto, K. & Sieber, V. (2014). Enzymatic Decarboxylation—An Emerging Reaction for Chemicals Production from Renewable Resources. ChemCatChem 6, 689-701.
    doi: 10.1002/cctc.201300881
  • Häßler, T., Schieder, D., Pfaller, R., Faulstich, M. & Sieber, V. (2014). Effects of Selected Yeast Extract Compounds on 2,3-Butanediol Production by Paenibacillus polymyxa DSM 365. Current Biotechnology 3, 157-165.
    doi: 10.2174/2211550102666140227000520
  • Inprakhon, P., Panlawan, P., Pongtharankul, T., Marie, E., Wiemann, L. O., Durand, A. & Sieber, V. (2014). Toward one-pot lipase-catalyzed synthesis of poly(ɛ-caprolactone) particles in aqueous dispersion. Colloids and Surfaces B: Biointerfaces 113, 254-260.
    doi: 10.1016/j.colsurfb.2013.09.011


  • Hofer, M., Strittmatter, H. & Sieber, V. (2013). Biocatalytic Synthesis of a Diketobornane as a Building Block for Bifunctional Camphor Derivatives. ChemCatChem 5, 3351-3357.
    doi: 10.1002/cctc.201300344
  • Steffler, F. & Sieber, V. (2013). Refolding of a Thermostable Glyceraldehyde Dehydrogenase for Application in Synthetic Cascade Biomanufacturing. PLoS ONE 8, e70592.
    doi: 10.1371/journal.pone.0070592
  • Steffler, F., Guterl, J.-K. & Sieber, V. (2013). Improvement of thermostable aldehyde dehydrogenase by directed evolution for application in Synthetic Cascade Biomanufacturing. Enzyme and Microbial Technology 53, 307-314.
    doi: 10.1016/j.enzmictec.2013.07.002
  • Pick, A., Rühmann, B., Schmid, J. & Sieber, V. (2013). Novel CAD-like enzymes from Escherichia coli K-12 as additional tools in chemical production. Applied Microbiology and Biotechnology 97, 5815-5824.
    doi: 10.1007/s00253-012-4474-5
  • Reiter, J., Strittmatter, H., Wiemann, L. O., Schieder, D. & Sieber, V. (2013). Enzymatic cleavage of lignin beta-O-4 aryl ether bonds via net internal hydrogen transfer. Green Chemistry 15, 1373-1381.
    doi: 10.1039/C3GC40295A
  • Flemke, J., Maywald, M. & Sieber, V. (2013). Encapsulation of Living E. coli Cells in Hollow Polymer Microspheres of Highly Defined Size. Biomacromolecules 14, 207-214.
    doi: 10.1021/bm3016362
  • Guterl, J.-K. & Sieber, V. (2013). Biosynthesis “debugged”: Novel bioproduction strategies. Engineering in Life Sciences 13, 4-18.
    doi: 10.1002/elsc.201100231


  • Häßler, T., Schieder, D., Pfaller, R., Faulstich, M. & Sieber, V. (2012). Enhanced fed-batch fermentation of 2,3-butanediol by Paenibacillus polymyxa DSM 365. Bioresource Technology 124, 237-244.
    doi: 10.1016/j.biortech.2012.08.047
  • Wiemann, L., Faltl, C. & Sieber, V. (2012). Lipase-mediated Epoxidation of the Cyclic Monoterpene Limonene to Limonene Oxide and Limonene Dioxide. Zeitschrift für Naturforschung B 67, 1056–1060.
    doi: 10.5560/znb.2012-0167
  • Janker-Obermeier, I., Sieber, V., Faulstich, M. & Schieder, D. (2012). Solubilization of hemicellulose and lignin from wheat straw through microwave-assisted alkali treatment. Industrial Crops and Products 39, 198-203.
    doi: 10.1016/j.indcrop.2012.02.022
  • Guterl, J.-K., Garbe, D., Carsten, J., Steffler, F., Sommer, B., Reiße, S., Philipp, A., Haack, M., Rühmann, B., Koltermann, A., Kettling, U., Brück, T. & Sieber, V. (2012). Cell-Free Metabolic Engineering: Production of Chemicals by Minimized Reaction Cascades. ChemSusChem 5, 2165-2172.
    doi: 10.1002/cssc.201200365
  • Kolb, M., Sieber, V., Amann, M., Faulstich, M. & Schieder, D. (2012). Removal of monomer delignification products by laccase from Trametes versicolor. Bioresource Technology 104, 298-304.
    doi: 10.1016/j.biortech.2011.11.080


  • Schmid, J., Meyer, V. & Sieber, V. (2011). Scleroglucan: biosynthesis, production and application of a versatile hydrocolloid. Applied Microbiology and Biotechnology 91, 937-947.
    doi: 10.1007/s00253-011-3438-5
  • Schmid, J., Muller-Hagen, D., Bekel, T., Funk, L., Stahl, U., Sieber, V. & Meyer, V. (2010). Transcriptome sequencing and comparative transcriptome analysis of the scleroglucan producer Sclerotium rolfsii. BMC Genomics 11, 329.
    doi: 10.1186/1471-2164-11-329


  • Vorhölter, F.-J., Schneiker, S., Goesmann, A., Krause, L., Bekel, T., Kaiser, O., Linke, B., Patschkowski, T., Rückert, C., Schmid, J., Sidhu, V. K., Sieber, V., Tauch, A., Watt, S. A., Weisshaar, B., Becker, A., Niehaus, K. & Pühler, A. (2008). The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis. Journal of Biotechnology 134, 33-45.
    doi: 10.1016/j.jbiotec.2007.12.013


  • Butler, T., Alcalde, M., Sieber, V., Meinhold, P., Schlachtbauer, C. & Arnold, F. H. (2003). Functional Expression of a Fungal Laccase in Saccharomyces cerevisiae by Directed Evolution Applied and Environmental Microbiology 69, 987-995.
    doi: 10.1128/AEM.69.2.987-995.2003


  • Martin, A., Sieber, V. & Schmid, F. X. (2001). In-vitro Selection of Highly Stabilized Protein Variants with Optimized Surface. Journal of Molecular Biology 309, 717-726.
    doi: 10.1006/jmbi.2001.4698
  • Sieber, V., Martinez, C. A. & Arnold, F. H. (2001). Libraries of hybrid proteins from distantly related sequences. Nat Biotech 19, 456-460.
    doi: 10.1038/88129


  • Sieber, V., Pluckthun, A. & Schmid, F. X. (1998). Selecting proteins with improved stability by a phage-based method. Nat Biotech 16, 955-960.
    doi: 10.1038/nbt1098-955
  • Heffron, S., Moe, G. R., Sieber, V., Mengaud, J., Cossart, P., Vitali, J. & Jurnak, F. (1998). Sequence Profile of the Parallel β Helix in the Pectate Lyase Superfamily. Journal of Structural Biology 122, 223-235.
    doi: 10.1006/jsbi.1998.3978
  • Schindler, T., Perl, D., Graumann, P., Sieber, V., Marahiel, M. A. & Schmid, F. X. (1998). Surface-exposed phenylalanines in the RNP1/RNP2 motif stabilize the cold-shock protein CspB from Bacillus subtilis. Proteins: Structure, Function, and Bioinformatics 30, 401-406.
    doi: 10.1002/(SICI)1097-0134(19980301)30:4<401::AID-PROT7>3.0.CO;2-L


  • Sieber, V. & Moe, G. R. (1996). Interactions Contributing to the Formation of a β-Hairpin-like Structure in a Small Peptide. Biochemistry 35, 181-188.
    doi: 10.1021/bi950681o


  • Sieber, V., Jurnak, F. & Moe, G. R. (1995). Circular dichroism of the parallel β helical proteins pectate lyase C and E. Proteins: Structure, Function, and Bioinformatics 23, 32-37.
    doi: 10.1002/prot.340230105


  • Schmid, J., B. Rühmann, V. Sieber, L. Romero-Jiménez, J. Sanjuán, and D. Pérez-Mendoza, Screening of c-di-GMP-Regulated Exopolysaccharides in Host Interacting Bacteria, in Host-Pathogen Interactions: Methods and Protocols, C. Medina and F.J. López-Baena, Editors. (2018), Springer New York: New York, NY. p. 263-275.
  • Schmid, J., Mueller-Hagen, D., Sieber, V. & Meyer, V. (2013). Nucleic and Protein Extraction Methods for Fungal Exopolysaccharide Producers. In Laboratory Protocols in Fungal Biology (Gupta, V. K., Tuohy, M. G., Ayyachamy, M., Turner, K. M. & O’Donovan, A., eds.), pp. 427-434. Springer New York.
  • Schmid, J., Stahl, U. & Meyer, V. (2009). Genetic and Metabolic Engineering in Filamentous Fungi. In Physiology and Genetics, pp. 377-392.
  • Zuccarello, G., Critchley, A., Smith, J., Sieber, V., Lhonneur, G. & West, J. (2007). Systematics and genetic variation in commercial Kappaphycus and Eucheuma (Solieriaceae, Rhodophyta). In Eighteenth International Seaweed Symposium (Anderson, R., Brodie, J., Onsøyen, E. & Critchley, A., eds.), Vol. 1, pp. 417-425. Springer Netherlands.
  • Sieber, V., Wittmann, E. & Buchholz, S. (2005). Polysaccharide. In Lehrbuch für Angewandte Mikrobiologie (Antranikian, P. G., ed.), pp. 399-410. Springer Verlag.
  • Udit, A. K., Silberg, J. J. & Sieber, V. (2003). Sequence Homology-Independent Protein Recombination (SHIPREC). In Directed Evolution Library Creation (Arnold, F. & Georgiou, G., eds.), Vol. 231, pp. 153-163. Humana Press.
  • Sieber, V. (2003). Selection for Soluble Proteins via Fusion with Chloramphenicol Acetyltransferase. In Directed Enzyme Evolution (Arnold, F. & Georgiou, G., eds.), Vol. 230, pp. 45-55. Humana Press.
  • Martin, A., Schmid, F. X. & Sieber, V. (2003). Proside: A Phage-Based Method for Selecting Thermostable Proteins, Vol. 230, pp. 57-70.
  • Bulter, T., Sieber, V. & Alcalde, M. (2003). Screening Mutant Libraries in Saccharomyces cerevisiae. In Directed Enzyme Evolution (Arnold, F. & Georgiou, G., eds.), Vol. 230, pp. 99-107. Humana Press.


  • Csepei, Lenard-Istvan; Steffler, Fabian; Gaertner, Tobias; Sieber, Volker (2017) Regenerative synthesis of chemical stored energy sources and fine chemicals. WO 2017153396 A1 20170914.
  • Gaertner, Tobias; Kaiser, Manuela; Sieber, Volker; Soeldner, Anika; Koenig, Burkhard; Iwanow, Melanie (2016) Pyrolytic method for the production of particles containing at least one metal species. WO 2016180973 A1 20161117.
  • Sieber, Volker; Pick, Andre; Ruehmann, Broder (2015) Process for the enzymatic production of c4 compounds from c6 substrates, US 9169500 B2 20151027
  • Falcke, Claudia; Strittmatter, Harald; Woelbing, Marion; Sieber, Volker (2016) Terpene lactam-based polyamides. Ger. Offen., DE 102014221061 A1 20160421
  • Kraus, Michael; Koltermann, Andre; Kettling, Ulrich; Garbe, Daniel; Brueck, Thomas; Guterl, Jan-Karl; Sieber, Volker (2014) Cell-free and minimized metabolic reaction cascades for the production of chemicals. Pat. Appl., EP 2700714 A1 20140226.
  • Karau, Andreas; Sieber, Volker; Haas, Thomas; Haeger, Harald; Grammann, Katrin; Buehler, Bruno; Blank, Lars; Schmid, Andreas (2009) Production of ω-aminocarboxylic acids or their lactams by recombinant bacteria PCT Int. Appl., WO 2009077461 A1 20090625
  • Sieber, V., Pick, A. & Rühmann, B. (2011) Synthetic pathway for the production of alcohols or amines. EP2503003 A1
  • Sieber, V., Grammann, K., Rühmann, B., Haas, T., Pfeffer, J., Doderer, K., Rollmann, C., Skerra, A., Rausch, C. & Lerchner, A. (2010) Method for producing multicyclical ring systems carrying amino groups. WO2010089171 A2
  • Koltermann, A., Kettling, U. & Sieber, V. (2010) Process for cell-free production of chemicals. WO2010076305 A1
  • Sieber, V., Kaiser, J., Ruehmann, B., Potgrave, N., Wittmann, E. M., Marx, A., Windhab, N., Ewering, C., Kroll, J., Schulze, G. C., Pruefer, D., Steinbuechel, A., Wurbs, D., Bacher, A., Eisenreich, W., Graewert, T. W., Illarinova, V., Groll, M. & Rohdich, F. (2009) Mikrobiologische herstellung von isoprenoiden. WO2009030654 A1
  • Jäger, A., Rühmann, B. & Sieber, V. (2009) Producing an acylated polymer with a low degree of acylation, especially xanthan gum, comprises culturing a polymer-producing microorganism that has been modified to overexpress an acylase. DE102007041861 A1
  • Jäger, A., Rühmann, B. & Sieber, V. (2007) Herstellung von Polymeren mit reduziertem Acylgehalt. DE102007041861 A1
  • Loetzbeyer, T., Sieber, V., Volland, M. & Wittmann, E. (2005) Verfahren zur enzymatischen herstellung von mono- und diacylglycerid-haltigen emulgatoren. WO2005024036 A3
  • Deck, D. & Sieber, V. (2004) Verfahren zur Detektion und Quantifizierung von Bakterien in einer Probe. DE10311924 A1
  • Sieber, V. (2003) Method for producing gene libraries. WO2002068634 A3
  • Arnold, F. H., Sieber, V. & Zhang, J. H. (2002) Production of functional hybrid genes and proteins. WO2001030998 A9
  • Sieber, V. & Schmid, F. X. (1998) A bacteriophage infectivity assay for rapid screening of proteins to identify variants with increased stability. DE 19980302


Lehrstuhl Chemie Biogener Rohstoffe

Schulgasse 16
94315 Straubing


Prof. Dr. Volker Sieber

Tel.: +49 (0) 9421 187-300
Tel: +49 (0) 8161 71 35 91
Fax: +49 (0) 9421 187-310


Elisabeth Aichner

Tel.: +49 (0) 9421 187-301
Fax: +49 (0) 9421 187-310