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Publikationen

Begutachtete Zeitschriftenartikel

  1. Graf, M., J. Zieringer, T. Haas, A. Nieß, B. Blombach, and R. Takors. 2018. Physiological response of Corynebacterium glutamicum to increasingly nutrient-rich growth conditions. Front. Microbiol. 9 :2058.
  2. Lange, J., E. Münch, J. Müller, T. Busche, J. Kalinowski, R. Takors, and B. Blombach. 2018. Deciphering the adaptation of Corynebacterium glutamicum in transition from aerobiosis via microaerobiosis to anaerobiosis. Genes. 9:297.
  3. Failmezger, J., S. Scholz, B. Blombach, and M. Siemann-Herzberg. 2018. Cell-free protein synthesis from fast-growing Vibrio natriegens. Front. Microbiol. 9:1146.
  4. Shah, A., B. Blombach, R. Gauttam, and B. J. Eikmanns. 2018. The RamA regulon: complex regulatory interactions in relation to central metabolism in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 102:5901-5910.
  5. Takors, R., M. Kopf, J. Mampel, W. Bluemke, B. Blombach, B. Eikmanns, FR Bengelsdorf, D. Weuster-Botz, and P. Dürre. 2018. Using gas mixtures of CO, CO2 and H2 as microbial substrates: the do’s and don’ts of successful technology transfer from laboratory to production scale. Microb. Biotechnol. 11:606-625.
  6. Schwentner, A., A. Feith, E. Münch, T. Busche, C. Rückert, J. Kalinowski, R. Takors, and B. Blombach. 2018. Metabolic engineering to guide evolution – creating a novel mode for L-valine production with Corynebacterium glutamicum. Metab. Eng. 47:31-41.
  7. Lange, J., F. Müller, R. Takors, and B. Blombach. 2018. Harnessing novel chromosomal integration loci to utilize an organosolv-derived hemicellulose fraction for isobutanol production with engineered Corynebacterium glutamicum. Microb. Biotechnol. 11:257-263.
  8. Lange, J., F. Müller, K. Bernecker, N. Dahmen, R. Takors, and B. Blombach. 2017. Valorization of pyrolysis water – a biorefinery side stream – for 1,2-propanediol production with engineered Corynebacterium glutamicum. Biotechnol. Biofuels. 10:277.
  9. Hoffart, E., S. Grenz, J. Lange, R. Nitschel, F. Müller, A. Schwentner, A. Feith, M. Lenfers-Lücker, R. Takors, and B. Blombach. 2017. High substrate uptake rates empower Vibrio natriegens as production host for industrial biotechnology. Appl. Environ. Microbiol. 83:e01614-17.
  10. Radoš, D., D. L. Turner, T. Catarino, E. Hoffart, A. R. Neves, B. J. Eikmanns, B. Blombach, and H. Santos. 2016. Stereospecificity of Corynebacterium glutamicum 2,3-butanediol dehydrogenase and implications for the stereochemical purity of bioproduced 2,3-butanediol. Appl. Microbiol. Biotechnol. 100:10573-10583.
  11. Lange, J., R. Takors, and B. Blombach. 2016. Zero-growth bioprocesses – A challenge for microbial production strains and bioprocess engineering. Eng. Life Sci. 17:27-35.
  12. Zetzmann, M., A. Sánchez-Kopper, M. S. Waidmann, B. Blombach, and C. U. Riedel. 2016. Identification of the agr peptide of Listeria monocytogenes. Front. Microbiol. 7:989.
  13. Radoš, D., A. L. Carvalho, S. Wieschalka, A. R. Neves, B. Blombach, B. J. Eikmanns, and H. Santos. 2015. Engineering Corynebacterium glutamicum for the production of 2,3‑butanediol. Microb. Cell Fact. 14:171.
  14. Blombach, B., and R. Takors. 2015. CO2 – intrinsic product, essential substrate and regulatory trigger of microbial and mammalian production processes. Front. Bioeng. Biotechnol. 3:108.
  15. Buchholz, J., M. Graf, A. Freund, T. Busche, J. Kalinowski, B. Blombach, and R. Takors. 2014. CO2/HCO3− perturbations of simulated large scale gradients in a scale-down device cause fast transcriptional responses in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 98:8563-8572.
  16. Buchholz, J., M. Graf, B. Blombach, and R. Takors. 2014. Improving the carbon balance of fermentations by total carbon analysis. Biochem. Eng. J. 90:162-169.
  17. Oldiges, M., B. J. Eikmanns, and B. Blombach. 2014. Application of metabolic engineering for the biotechnological production of L-valine. Appl. Microbiol. Biotechnol. 98:5859-5870.
  18. Radoš, D., D. L. Turner, L. L. Fonseca, A. L. Carvalho, B. Blombach, B. J. Eikmanns, A. R. Neves, and H. Santos. 2014. The effect of CO2 on anaerobic succinate production by Corynebacterium glutamicum: carbon flux analysis by 13C-NMR. Appl. Environ. Microbiol. 80:3015-3024.
  19. Eikmanns, B. J., and B. Blombach. 2014. The pyruvate dehydrogenase complex of Corynebacterium glutamicum: An attractive target for metabolic engineering. J. Biotechnol. 192:339-345.
  20. Mustafi, N., A. Grünberger, R. Mahr, S. Helfrich, K. Nöh, B. Blombach, D. Kohlheyer, and J. Frunzke. 2014. Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains. PloS ONE. 9:e85731.
  21. Blombach, B., J. Buchholz, T. Busche, J. Kalinowski, and R. Takors. 2013. Impact of different CO2/HCO3- levels on metabolism and regulation in Corynebacterium glutamicum. J. Biotechnol. 168:331-340.
  22. Buchholz, J., A. Schwentner, B. Brunnenkan, C. Gabris, S. Grimm, R. Gerstmeir, R. Takors, B. J. Eikmanns, and B. Blombach. 2013. Platform Engineering of Corynebacterium glutamicum with reduced pyruvate dehydrogenase complex activity for improved production of L-lysine, L-valine, and 2-ketoisovalerate. Appl. Environ. Microbiol. 79:5566-5575.
  23. Wieschalka, S., B. Blombach, M. Bott, and B. J. Eikmanns. 2012. Bio-based production of organic acids with Corynebacterium glutamicum. Microb. Biotechnol. 6:87-102.
  24. Wieschalka, S., B. Blombach, and B. J. Eikmanns. 2012. Engineering Corynebacterium glutamicum for the production of pyruvate. Appl. Microbiol. Biotechnol. 94:449-459.
  25. Blombach, B., T. Riester, S. Wieschalka, C. Ziert, J-W Youn, V. F. Wendisch, and B. J. Eikmanns. 2011. Corynebacterium glutamicum tailored for efficient isobutanol production. Appl. Environ. Microbiol. 77:3300–3310.
  26. Blombach, B., and B. J. Eikmanns. 2011. Current knowledge on isobutanol production with Escherichia coli, Bacillus subtilis and Corynebacterium glutamicum. Bioeng. Bugs. 2:1-5.
  27. Bartek T., B. Blombach, S. Lang, B. J. Eikmanns, W. Wiechert, M. Oldiges, K. Nöh, and S. Noack. 2011. Comparative 13C metabolic flux analysis of pyruvate dehydrogenase complex-deficient L-valine-producing Corynebacterium glutamicum. Appl. Environ. Microbiol. 77:6644–6652.
  28. Blombach, B., and G. M. Seibold. 2010. Carbohydrate metabolism in Corynebacterium glutamicum and applications for the metabolic engineering of L-lysine production strains. Appl. Microbiol. Biotechnol. 86:1313-22.
  29. Krause F. S., B. Blombach, and B. J. Eikmanns. 2010. Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production. Appl. Environ. Microbiol. 76:8053–8061.
  30. Bartek T., C. Rudolf, U. Kerßen, B. Klein, B. Blombach, S. Lang, B. J. Eikmanns, and M. Oldiges. 2010. Studies on substrate utilisation in L-valine-producing Corynebacterium glutamicum strains deficient in pyruvate dehydrogenase complex. Bioprocess. Biosyst. Eng. 33:873-883.
  31. Bartek T., B. Blombach, E. Zönnchen, P. Makus, S. Lang, B. J. Eikmanns, and M. Oldiges. 2010. Importance of NADPH supply for improved L-valine formation in Corynebacterium glutamicum. Biotechnol. Prog. 26:361-71.
  32. Krause F., A. Henrich, B. Blombach, R. Krämer, B. J. Eikmanns, and G. M. Seibold. 2010. Maltose improves glucose utilization in Corynebacterium glutamicum: Application for the improvement of L-valine productivity. Appl. Environ. Microbiol. 76:370-374.
  33. Blombach, B., A. Arndt, M. Auchter, and B. J. Eikmanns. 2009. L-Valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR. Appl. Environ. Microbiol. 75:1197-1200.
  34. Blombach, B., A. Cramer, B. J. Eikmanns, and M. E. Schreiner. 2009. RamB is an activator of the pyruvate dehydrogenase complex subunit E1p gene in Corynebacterium glutamicum. J. Mol. Microbiol. Biotechnol. 16:236-239.
  35. Blombach, B., S. Hans, B. Bathe, and B. J. Eikmanns. 2009. Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum. Appl. Environ. Microbiol. 75:419-427.
  36. Blombach, B., M. E. Schreiner, T. Bartek, M. Oldiges, and B. J. Eikmanns. 2008. Corynebacterium glutamicum tailored for high-yield L-valine production. Appl. Microbiol. Biotechnol. 79:471-479.
  37. Blombach, B., M. E. Schreiner, J. Holátko, T. Bartek, M. Oldiges, and B. J. Eikmanns. 2007. L-Valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum. Appl. Environ. Microbiol. 73:2079-2084.
  38. Blombach, B., M. E. Schreiner, M. Moch, M. Oldiges, and B. J. Eikmanns. 2007. Effect of pyruvate dehydrogenase complex deficiency on L-lysine production with Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 76:615-623.

Nicht begutachtete Zeitschriftenartikel

  1. Blombach B., K. Castiglione, T. Haarmann, and J. Schmid. 2015. Mikrobielle Stammentwicklung: Trends in der Genomeditierung für die industrielle Biotechnologie. BIOspektrum. 21:788-790.
  2. Blombach B., and B. J Eikmanns. 2014. Corynebacterium glutamicum als Produzent von Pyruvat-abgeleiteten Produkten. BIOspektrum. 20:696-699.

Buchkapitel

Bioprocessing of renewable resources to commodity bioproducts. 2014. V. S. Bisaria and A. Kondo (Ed.). Chapter 12: Isobutanol, B. J. Eikmanns and B. Blombach.

Patente

Bathe B., B. Blombach, B. J. Eikmanns, V. Engels, G. Thierbach, and V. F. Wendisch. 2012. Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the sugR gene is present in attenuated form. US 08,133,714; US 08,592,177.

Kontakt

Professur Mikrobielle Biotechnologie

Schulgasse 22
94315 Straubing

Leitung

Prof. Dr. Bastian Blombach

Tel.: +49 (0) 9421 187-105
Fax: +49 (0) 9421 187-130
E-Mail: bastian.blombach@tum.de